Women's Health Weekly
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Breast Cancer
Progesterone used to inhibit human breast cancer cell growth
January 5th, 2006
Progesterone could be used to inhibit human breast cancer cell growth. "The effects of progesterone derivatives on breast cancer development are still controversial, probably accounting for their biphasic, opposed effects on mammary cell-cycle regulation. Here, we demonstrate in vitro that the growth-inhibitory effects of progesterone on breast cancer T-47D cells require the transcriptional upregulation of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) gene," investigators in France reported. "A statistical analysis of human tumor biopsies further indicates that p27 mRNA levels correlate to progesterone receptor (PR) levels. Moreover, p27 gene...
Source: Women's Health Weekly (2006-01-05)
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