Women's Health Weekly
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Cancer Gene Therapy
Polyplex targeting enables gene transfer into human ovarian carcinoma cells
January 5th, 2006
A study from the Netherlands has documented the application of poly(2-(dimethylamino)ethyl methacrylate) (pDMAEMA)-based polyplexes for gene transfer into human ovarian carcinoma (OVAR-3) cells. "Previously, attempts were made in our laboratory to transfect human OVCAR-3 cells, growing in the peritoneal cavity of nude mice, by intraperitoneal administration of pDMAEMA)-based polyplexes. However, hardly any transfection of the OVCAR-3 cells was observed," investigators in the Netherlands report. "The aim of the present study was to examine whether pDMAEMA-polyplexes can transfect OVCAR-3 cells in vivo at DNA doses much higher than used previously [J....
Source: Women's Health Weekly (2006-01-05)
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