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HIV/AIDS Therapy

Imiquimod and CpG ODN induce antiviral cytokines but do not prevent vaginal SIV

Published in Women's Health Weekly, January 5th, 2006

The toll-like receptor 7 (TLR7) agonist imiquimod and the TLR9 agonist CpG ODN induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques.

According to recent research from the United States, "The initial host response to viral infection occurs after Toll-like receptors (TLRs) on dendritic cells (DC) are stimulated by viral nucleic acids (double-stranded RNA, single-stranded RNA) and alpha interferon (IFN-alpha) and IFN-beta are produced. We hypothesized that pharmacologic induction of innate antiviral responses in the cervico-vaginal mucosa by topical application of...

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