Published in Women's Health Weekly, January 12th, 2006
Study 1: Hypoxia-inducible factor 1 (HIF-1) mediates estrogen-induced stimulation of VEGF (vascular endothelial growth factor).
According to recent research published in the journal Molecular Endocrinology, "VEGF plays a pivotal role in the regulation of microvascular permeability and angiogenesis, processes essential for normal endometrial growth and implantation. Estrogen [17 beta-estradiol (E-2)], via its receptor (ER alpha), rapidly stimulates VEGF expression in the uterus at the transcriptional level."
"The...
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