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Women's Health Weekly

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Breast Cancer



Estrogen and high LET-radiation induced breast cancer tumorigenesis



January 12th, 2006

Researchers suggested estrogen and high linear energy transfer (LET)-radiation induce breast cancer tumorigenesis.

According to recent research from the United States, "Breast cancer is a complex disease involving numerous genetic aberrations. Immunochemical analysis of protein expression is presented in a human breast epithelial cell line neoplastically transformed by high LET alpha particle radiation in the presence of 17 beta estradiol (E) and in the parental human breast epithelial cell line (MCF-10F) which served as a non-tumorigenic control."

"The aim of this work was to determine the levels of mRNA and protein expression in control and...


Source: Women's Health Weekly (2006-01-12)

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