Women's Health Weekly
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Breast Cancer
Novel group of genes regulates drug susceptibility in breast cancer cells
January 12th, 2006
Research from the United States has documented that a novel group of genes regulates susceptibility to antineoplastic drugs in highly tumorigenic breast cancer cells. "Doxorubicin is an anthracycline antibiotic used for cancer chemotherapy. The utility of doxorubicin is limited by its inability to kill all of the cells within a tumor and by resistant cells emerging from the treated population." "We have screened for genes that regulate doxorubicin susceptibility in highly tumorigenic breast cancer cells by cDNA microarray and RNA interference (RNAi) analysis, and we have identified genes associated with both proliferation and cell cycle arrest after...
Source: Women's Health Weekly (2006-01-12)
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