Women's Health Weekly
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Breast Cancer
Polymorphisms of the BRCA2 gene associated with breast cancer
January 12th, 2006
Polymorphisms of the BRCA2 gene were associated with breast cancer. "We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR-RFLP," scientists in Poland reported. "Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant was associated with significant reduction in breast cancer risk. Gene-gene interaction between the BRCA2-Met1915Thr Thr/Thr and BRCA2-Met784Val Met/Met homozygous variants increased the risk,"...
Source: Women's Health Weekly (2006-01-12)
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