Women's Health Weekly
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Breast Cancer
[F-18]FLT-positron emission tomography used to quantify cellular proliferation
January 12th, 2006
3'-Deoxy-3'-[F-18]fluorothymidine ([F-18]FLT)-positron emission tomography could be used to quantify cellular proliferation in breast cancer. According to recent research from England, "There is an unmet need to develop imaging methods for the early and objective assessment of breast tumors to therapy. [F-18]FLT-positron emission tomography represents a new approach to imaging thymidine kinase activity, and hence, cellular proliferation. We compare graphical, spectral, and semiquantitative analytic methodologies for quantifying [F-18]FLT kinetics in tumor and normal tissue of patients with locally advanced and metastatic breast cancer." "The...
Source: Women's Health Weekly (2006-01-12)
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