Women's Health Weekly
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Cancer Gene Therapy
PKR-induced mammalian cell death tested in an antisense cellular screening assay
January 12th, 2006
Recent research from Israel has described an antisense cellular screening assay to test the ability of PKR to induce cell death in mammalian cells. "Long double-stranded RNA (>30 bp), usually expressed in cells infected with RNA viruses, triggers antiviral responses that induce apoptosis of the infected cells." "PKR can be selectively activated in glioblastoma cells by in situ generation of dsRNA following introduction of antisense RNA complementary to an RNA expressed specifically in these cells," wrote I. Friedrich and colleagues, Hebrew University of Jerusalem. "Harnessing PKR for the selective killing of cancer cells is...
Source: Women's Health Weekly (2006-01-12)
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