Women's Health Weekly
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Cancer Therapy
CTLA-4 provides a potential target for antitumor therapeutic intervention
January 12th, 2006
CTLA-4 (CD152) is expressed and functional on human tumor cells, providing a potential target for antitumor therapeutic intervention. According to recent research published in the International Journal of Cancer, "CTLA-4 is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. We have previously shown that CTLA-4 is also expressed on neoplastic lymphoid and myeloid cells, and it can be targeted to induce apoptosis." "In our study, we have extended our analysis and have discovered that surface expression of CTLA-4 is detectable by flow cytometry on 30 of 34 (88%) cell lines...
Source: Women's Health Weekly (2006-01-12)
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