Osteoporosis
Bisphosphonate treatment doesn't affect osteoblasts in improved in vitro model
Published in Women's Health Weekly, January 19th, 2006
"Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption," researchers in Australia explained. "Recent interest has centered on the effects of bisphosphonates on osteoblasts."
"Chronic dosing of osteoblasts with solubilized bisphosphonates has been reported to enhance osteogenesis and mineralization in vitro," noted A. Schindeler and colleagues at Children's Hospital Westmead in Sydney. "However, this methodology poorly reflects the in vivo situation, where free bisphosphonate becomes rapidly bound to mineralized bone...
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