Pulmonary Medicine
Preterm birth changes hypoxia-inducible factor production in the lung tissues of primate models
Published in Women's Health Weekly, January 19th, 2006
"Diminished vascular and alveolar development is characteristic of bronchopulmonary dysplasia (BPD). The low fetal O2 tension promotes angiogenic responses during ontogenesis, while preterm birth interrupts normal lung growth," researchers in the United States report.
"Most of the angiogenic responses are governed by HIFs, the expressions of which are unknown in the lungs of preterm primates. Lung tissue was harvested from fetal third-trimester baboons as well as from preterm baboons (67% or 75% of term gestation) treated with mechanical...
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