Women's Health Weekly
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Breast Cancer
Double staining of MIB-1 and AgNORs used to predict lymph node metastasis
January 19th, 2006
Double staining of MIB-1 and argyrophilic nucleolar organizer regions (AgNORs) could be used to predict lymph node metastasis of patients with breast cancer. According to a study from Japan, "AgNORs and MIB-1 as proliferating activities have been applied separately to assess the malignant potential of cancer cells. We conducted staining of AgNORs and MIB-1 in 42 surgically-resected invasive breast carcinomas. Paraffin-embedded sections were used for double staining and the mean AgNOR counts in 100 MIB-1-positive and -negative cells were calculated." "The mean AgNOR count in MIB-1-positive cells was significantly higher than in MIB-1-negative ones....
Source: Women's Health Weekly (2006-01-19)
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