Women's Health Weekly
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Breast Cancer Therapy
Expression changes in multiple genes result from estradiol-deprived breast cancer cells
January 19th, 2006
Expression changes in multiple genes result from estradiol-deprived MCF-7 breast cancer cells. "First-line treatment of hormone dependent breast cancer initially causes tumor regression but later results in adaptive changes and tumor re-growth," according to scientists in the United States. "Responses to second-line treatments occur but tumors again begin to progress after a period of 12-18 months. In depth understanding of the adaptive process would allow the identification of targets to abrogate the development of hormonal resistance and prolong the efficacy of endocrine therapy." R.J. Santen and colleagues asserted, "We have developed a model...
Source: Women's Health Weekly (2006-01-19)
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