Women's Health Weekly
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Cancer Gene Therapy
Akt blocks breast cancer cell motility and invasion
January 19th, 2006
According to recent research from the United States published in the journal Molecular Cell, Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT (nuclear factor of activated T cells). "The phosphoinositide 3-kinase (PI 3-K) signaling axis is intimately associated with deregulated cancer cell growth, primarily by promoting increased survival through Akt/PKB (protein kinase B). However, there is relatively little information on the role of Akt in cancer cell motility, a key phenotype of invasive carcinomas." "Here," wrote M. Yoelilerner and colleagues, Harvard University, "we report that activation of Akt...
Source: Women's Health Weekly (2006-01-19)
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