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Acute Coronary Syndromes

Acute coronary syndrome in postmenopausal women may be associated with ACE-DD genotype

Published in Women's Health Weekly, January 19th, 2006

Acute coronary syndrome in postmenopausal women may be associated with the ACE-DD genotype.

"The insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE), the A1166C polymorphism in the angiotensin type 1 receptor (AT1R), and the M235T polymorphism of the angiotensinogen gene are associated with cardiovascular disease mostly in men. Few data are available on the effects of these genetic variations in postmenopausal women according to hormone replacement therapy (HRT) use," according to investigators in Canada.

J. Methot and colleagues wrote, "In this case-control study, we determine the frequency of mutant alleles in the ACE...

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