HIV/AIDS Transmission
Vaginal cells are selectively permissive to X4 HIV entry
Published in Women's Health Weekly, January 19th, 2006
According to recent research published in the Journal of Medical Virology, "X4 and R5 HIV strains are present in the semen of men infected with HIV but R5 isolates are transmitted preferentially. The role of human epithelial cells in this selection is addressed."
"Three human cervical cell lines - CaSki, SiHa, and HEC1A - and normal human vaginal cells from HIV-negative donors were characterized for HIV receptor expression and incubated with X4 and R5 laboratory-adapted strains or primary isolates.
"The infection was assessed by detection of intracellular HIV DNA....
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