Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Bone Formation
Calcineurin appears to regulate bone formation through an effect on osteoblast differentiation
January 26th, 2006
Calcineurin appears to regulate bone formation through an effect on osteoblast differentiation. "Two of the most commonly used immunosuppressants, cyclosporine A and tacrolimus (FK506), inhibit the activity of a ubiquitously expressed Ca2+/calmodulin-sensitive phosphatase, calcineurin. Because both drugs also cause profound bone loss in humans and in animal models, we explored whether calcineurin played a role in regulating skeletal remodeling," scientists in the United States reported. "We found that osteoblasts contained mRNA (messenger ribonucleic acid) and protein for all isoforms of calcineurin A and B. TAT-assisted transduction of fusion...
Source: Women's Health Weekly (2006-01-26)
|
