Women's Health Weekly
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Breast Cancer
Alpha6beta4 integrin depends on VEGF to maintain malignant breast tumor growth
January 26th, 2006
Alpha6beta4 integrin depends on vascular endothelial growth factor (VEGF) to maintain malignant breast tumor growth. "The alpha6beta4 integrin has been widely implicated in carcinoma function in vitro; however, in vivo data are scarce. To determine the importance of alpha6beta4 in tumor progression, a SUM-159 breast carcinoma cell line that is essentially devoid of alpha6beta4 expression was generated using an RNA interference strategy," investigators in the United States report. "Loss of alpha6beta4 expression inhibits colony formation in soft agar assays, suggesting a vital role for alpha6beta4 in survival signaling and anchorage-independent...
Source: Women's Health Weekly (2006-01-26)
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