Women's Health Weekly
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Breast Cancer
Angiogenic induction may be a key feature of hormone-dependent breast cancer
January 26th, 2006
Angiogenic induction may be a key feature of hormone-dependent breast cancer. "Angiogenesis is crucial in tumor development and progression. Ovarian hormones regulate angiogenesis in the reproductive tract but very little is known about its regulation in the normal breast," scientists in Sweden report. "Sex steroids play an important role in breast cancer development by poorly understood mechanisms. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) are potent stimulators of angiogenesis. Both VEGF and FGF-2 function in autocrine/paracrine pathways and there is a major contribution of bioactive proteins by a...
Source: Women's Health Weekly (2006-01-26)
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