Women's Health Weekly
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Breast Cancer
Overexpressed Twist alters angiogenesis and chromosomal stability in breast tumors
January 26th, 2006
Overexpressed Twist alters angiogenesis and chromosomal stability in breast tumors. "Aggressive cancer phenotypes are a manifestation of many different genetic alterations that promote rapid proliferation and metastasis. In this study, we show that stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein markers representative of a mesenchymal transformation," investigators in the United States report. "In addition, it was observed that MCF-7/Twist cells had increased vascular endothelial growth factor (VEGF) synthesis when compared with empty vector control...
Source: Women's Health Weekly (2006-01-26)
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