Women's Health Weekly
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Breast Cancer
RNA interference in breast cancer cells alters differentiation and proliferation
January 26th, 2006
According to research from the United States, RNA interference (RNAi)-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. "Choline kinase is overexpressed in breast cancer cells and activated by oncogenes and mitogenic signals, making it a potential target for cancer therapy," wrote K. Glunde and colleagues, Johns Hopkins University. "Here, we have examined, for the first time, the effects of RNA interference (RNAi) mediated down-regulation of choline kinase in nonmalignant and malignant human breast epithelial cell lines using magnetic resonance spectroscopy (MRS) as well as molecular...
Source: Women's Health Weekly (2006-01-26)
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