Women's Health Weekly
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Breast Cancer
The MCT-1 oncogene promotes tumor angiogenesis and blocks apoptosis
January 26th, 2006
The MCT-1 (multiple copies in a T cell malignancy) oncogene promotes tumor angiogenesis and blocks apoptosis. "Overexpression of a novel oncogene MCT-1 causes malignant transformation of murine fibroblasts. To establish its role in the pathogenesis of breast cancer in humans, we generated stable transfectants of MCF7 breast cancer cells negative for endogenous MCT-1 (MCF7-MCT-1)," researchers in the United States report. "Overexpression of MCT-1 in these cells resulted in a slight elevation of estrogen receptor-alpha, and higher rates of DNA synthesis and growth in response to estradiol compared with the empty vector control (MCF7-EV). The pure...
Source: Women's Health Weekly (2006-01-26)
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