Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer
BRCA1 methylation in breast cancer patients linked to reduced gene copy number
February 2nd, 2006
BRCA1 promoter methylation in sporadic breast cancer was associated with reduced gene copy number and chromosome 17 aneusomy. Investigators in the United States explained, "To explore the molecular mechanisms for the similarities between inherited and noninherited forms of breast cancer, we tested the hypothesis that inactivation of BRCA1 by promoter hypermethylation is associated with reduced gene copy number and chromosome 17 aneusomy as observed in tumors from BRCA1 mutation carriers. Using a combination of methylation-specific PCR analysis and fluorescence in situ hybridization, we observed varying degrees of promoter methylation in 39 of 131 (29.8%) primary...
Source: Women's Health Weekly (2006-02-02)
|
