Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer
Cyclin E overexpression transactivates expression of calpain 2
February 2nd, 2006
Cyclin E overexpression transactivates the expression of calpain 2, a protease implicated in the progression of breast cancer. According to recent research from the United States, "Overexpression of cyclin E in breast tumors is associated with a poor response to tamoxifen therapy, greater genomic instability, more aggressive behavior, and a poor clinical prognosis. These tumors also express low molecular weight isoforms of cyclin E that are associated with higher kinase activity and increased metastatic potential." "In the current study, we show that cyclin E overexpression in MCF7 cells transactivates the expression of calpain 2, leading to...
Source: Women's Health Weekly (2006-02-02)
|
