Women's Health Weekly
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Breast Cancer
TCDD induces tumorigenicity in breast epithelial cells
February 2nd, 2006
2,3,7,8-Tetrachlorodibenzo-p-clioxin induces tumorigenicity in breast epithelial cells. According to a study from South Korea, "Although 2,3,7,8-tetrachlorodibenzo-p-clioxin (TCDD) has a variety of carcinogenic and noncarcinogenic effects in experimental animals, its role in human carcinogenicity remain controversial. "A simian virus 40-immortalized cell line from normal human breast epithelial cells with stem cells and luminal characteristic (M13SV1) was used to study whether TCDD can induce A1G positive colony formation and cause increased cell numbers in a inverted U-shaped dose-response manner." "TCDD activated Akt, ERK2, and...
Source: Women's Health Weekly (2006-02-02)
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