Women's Health Weekly
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Breast Cancer
Matrix metalloproteinase-1 implicated in breast tumor growth
February 9th, 2006
Matrix metalloproteinase-1 (MMP-1) was implicated in breast tumor growth. According to recent research from the United States, "Increased MMP-1 expression is associated with advanced stages of breast cancer and may be a predictive marker for the development of invasive disease. In this report, we used short hairpin RNA (shRNA) molecules to investigate whether MMP-1 production in MDA-231 breast cancer cells contributed to the degradation of a collagen matrix or tumor formation in nude mice." "We created 2 groups of MDA-231 cell lines. MDA-231 cells containing a vector producing shRNA specific for NINIP-1 had a >90% decrease in MMP-1 mRNA and...
Source: Women's Health Weekly (2006-02-09)
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