Women's Health Weekly
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Breast Cancer
Melatonin enhanced inhibitory effect of aminoglutethimide in breast cancer cells
February 9th, 2006
Melatonin enhanced the inhibitory effect of aminoglutethimide in MCF-7 human breast cancer cells. According to recent research from Spain, "The inhibition of the aromatase-induced intratumoral estrogen synthesis is one of the main anticancer pharmacological strategies. The aim of this paper was to study if a melatonin pretreatment prior to aminoglutethimide increases the efficiency of the aromatase inhibitor used in treating breast cancer." "Aminoglutethimide (100 mcM) and melatonin (1 nM) significantly decreased cellular aromatase activity in unpretreated MCF-7 cells. A sequential regimen of melatonin (1 nM) followed 24 h later by aminoglutethimide...
Source: Women's Health Weekly (2006-02-09)
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