Women's Health Weekly
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Breast Cancer
PrxII expression related to radiation-resistant MCF-7 breast cancer cells
February 9th, 2006
Peroxiredoxin II (PrxII) expression could be associated with radiation-resistant MCF-7 breast cancer cells. According to a study from the United States, "Although several signaling pathways have been suggested to be involved in the cellular response to ionizing radiation, the molecular basis of tumor resistance to radiation remains elusive. We have developed a unique model system based upon the MCF-7 human breast cancer cell line that became resistant to radiation treatment (MCF+FIR30) after exposure to chronic ionizing radiation." "By proteomics analysis, we found that peroxiredoxin II (PrxII), a member of a family of peroxidases, is up-regulated in...
Source: Women's Health Weekly (2006-02-09)
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