Women's Health Weekly
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Cancer Therapy
Novel extracellular vesicles mediated anticancer drug resistance
February 9th, 2006
Novel extracellular vesicles could mediate anticancer drug sequestration and resistance. According to recent research from Israel, "Overexpression of the multidrug efflux transporter ABCG2 in the plasma membrane of cancer cells confers resistance to various anticancer drugs, including mitoxantrone. Here, we explored the mechanism underlying drug resistance in the MCF-7 breast cancer sublines MCF-7/MR and MCF-7/FLV1000 cells in which wild-type (11482) ABCG2 overexpression is highly confined to cell-cell attachment zones." "The latter comprised the membrane of novel extracellular vesicles in which mitoxantrone was rapidly and dramatically sequestered....
Source: Women's Health Weekly (2006-02-09)
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