Women's Health Weekly
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Cancer Therapy
Oncolytic adenovirus expressing a p53 variant replicates in cervical cancer
February 9th, 2006
According to recent research from the Netherlands, oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer. "Rationale in the development of novel treatment strategies for HPV-associated cancers is targeting on the basis of the presence of HPV in (pre)malignant cells. Here, we designed a new conditionally replicating adenovirus (CRAd) for selective and effective oncolytic replication in HPV-containing cells." "As the backbone," wrote D.A.M. Heideman and colleagues, VU University, "we used the CRAd AdCB016, which replicates selectively in cells expressing HPV...
Source: Women's Health Weekly (2006-02-09)
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