Women's Health Weekly
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Cancer Therapy
Smad7 expression may repress metastasis of mouse mammary carcinoma cells
February 9th, 2006
According to a recent study published from Japan, Smad7 expression may repress metastasis of mouse mammary carcinoma cells. "Transforming growth factor beta (TGF-beta) facilitates metastasis during the advanced stages of cancer. Smad6, Smad7, and c-Ski block signaling by the TGF-beta superfamily proteins through different modes of action." "We used adenovirus-mediated gene transfer of these natural inhibitors in a mouse model of breast cancer to examine the roles of TGF-beta superfamily signaling in tumor growth and metastasis," wrote H. Azuma and colleagues, University of Tokyo. "We systemically administered, by intravenous...
Source: Women's Health Weekly (2006-02-09)
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