Women's Health Weekly

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Breast Cancer

Calcium signaling in cancer and vitamin D examined

According to recent research published in the Journal of Steroid Biochemistry and Molecular Biology, "Calcium signals induced by the Ca²⁺ regulatory hormone 1,25(OH)(2)D-3 may determine the fate of the cancer cell. We have shown that, in breast cancer cell lines, 1,25(OH)(2)D-3 induces a sustained increase in concentration of intracellular Ca²⁺ ([Ca²⁺](i)) by depleting the endoplasmic reticulum (ER) Ca²⁺ stores via inositol 1,4,5-trisphosphate receptor/Ca²⁺ release channel and activating Ca²⁺ entry from the extracellular space via...

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