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Breast Cancer Prevention

Review examines therapeutic value of selective estrogen receptor modulators in breast cancer

Published in Women's Health Weekly, February 16th, 2006

The therapeutic value of selective estrogen receptor modulators in breast cancer were recently reviewed in Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.

"Despite the beneficial effects of estrogens in women's health, there is a plethora of evidence that suggest an important role for these hormones, particularly 17 beta-estradiol (E2 ), in the development and progression of breast cancer. Most estrogenic responses are mediated by estrogen receptors (ERs), either ERalpha or ERbeta, which are members of the nuclear receptor superfamily of ligand-dependent transcription factors," explained investigators from the Fox Chase Cancer...

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