Women's Health Weekly
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Cancer Cell Biology
icb-1 gene expression is inducible in breast and ovarian cancer cells
February 16th, 2006
According to recent research from Germany, expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells. "Icb-1 (Clorf38) is a human gene initially described to be involved in in vitro differentiation processes of endometrial adenocarcinoma and leukemia cells. In this study, we examined the effect of interferon-gamma on icb-1 alpha and 0 mRNA levels in human cell lines derived from breast cancer and gynecological malignancies." "Furthermore," wrote O. Treeck and colleagues, University of Regensburg, "we intended to approach icb-1 gene function by...
Source: Women's Health Weekly (2006-02-16)
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