Women's Health Weekly
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Cancer Risk Factors
BRCA1 deficiency is linked to aberrant estrogen biosynthesis associated with cancer risk
February 16th, 2006
BRCA1 deficiency may be linked to aberrant estrogen biosynthesis which is associated with specific cancer risks. "Mutations in BRCA1 increase risks of familial breast and ovarian cancers, particularly among premenopausal women. While BRCA1 plays an active role in DNA repair, this function alone may not be sufficient to explain why BRCA1-associated tumors predominantly occur in estrogen-responsive tissues," investigators from the University of Virginia report. "Aromatase is the rate-limiting enzyme in estrogen biosynthesis and a key target in breast cancer treatment," explained Y.F. Hu and colleagues. "Aromatase expression in...
Source: Women's Health Weekly (2006-02-16)
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