Women's Health Weekly
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Breast Cancer
BRCA1 gene found to inhibit two sex hormones, not just one
February 23rd, 2006
It's been known that the breast cancer susceptibility gene BRCA1 regulates use of estrogen in breast and other cells, but now researchers at Georgetown University Medical Center have discovered that it also controls activity of progesterone. The findings, conducted in cell culture and in mice and reported by the researchers in the January 2006 issue of Molecular Endocrinology, could help explain why women who have mutations in their BRCA1 gene are susceptible to a number of different "hormone-dependent" cancers, including those of the breast, endometrium, and cervix. It also has implications for ordinary cancers that arise because a normal...
Source: Women's Health Weekly (2006-02-23)
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