Women's Health Weekly
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Breast Cancer
MDM2 protein expression is a negative prognostic marker in breast carcinoma
February 23rd, 2006
MDM2 protein expression is a negative prognostic marker in breast carcinoma. "The protein encoded by the MDM2 oncogene inhibits the function of p53, leading to increased cell growth, avoidance of apoptosis, tolerance of genetic instability, and resistance to chemotherapy. "The present study was performed to evaluate the relationship between MDM2 protein expression and survival in breast carcinoma," scientists writing in the journal Modern Pathology report. According to D.A. Turbin and colleagues at Vancouver General Hospital, "Two series of cases were used in this study: the first to identify the cutoff to be used in the...
Source: Women's Health Weekly (2006-02-23)
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