Women's Health Weekly
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Cancer Gene Therapy
Clusterin knockdown chemosensitizes human breast cancer cells
February 23rd, 2006
According to a study from Canada, knockdown of the cytoprotective chaperone, clusterin, chemosensitizes human breast cancer cells both in vitro and in vivo. "Clusterin is a stress-associated cytoprotective chaperone up-regulated by various apoptotic triggers in many cancers and confers treatment resistance when overexpressed. The objectives of this study were to evaluate clusterin expression levels in human breast cancer and to determine whether antisense oligonucleotides or double-stranded small interfering RNAs (siRNA) targeting the clusterin gene enhance apoptosis induced by paclitaxel," wrote A. So and colleagues, University of British Columbia. ...
Source: Women's Health Weekly (2006-02-23)
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