Cancer Therapy
Tamoxifen breast cancer therapy provokes distinct gene expression patterns in endometrial tissues
Published in Women's Health Weekly, February 23rd, 2006
"Tamoxifen treatment for breast cancer increases proliferation of the endometrium, resulting in an enhanced prevalence of endometrial pathologies, including endometrial cancer. An exploratory study was performed to begin to understand the molecular mechanism of tamoxifen action in the endometrium," scientists writing in the journal Endocrine-Related Cancer report.
"Gene-expression profiles were generated of endometrial samples of tamoxifen users and compared with matched controls. The pathological classification of samples from both groups included atrophic/inactive...
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