Women's Health Weekly
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Cervical Neoplasia
eIF4E used as marker for cervical neoplasia
February 23rd, 2006
eIF4E could be used as a marker for cervical neoplasia. According to a study from the United States, "Eukaryotic translation initiation factor 4E (eIF4E) is upregulated in cancers of the breast and head and neck. The authors have shown that eIF4E is increased in cervical neoplasia and that eIF4E upregulates human papillomavirus (HPV) oncoprotein E7. The aim of this study was to quantitate eIF4E in tissues representing a wide range of cervical pathology." "The potential correlation between dysplastic grade or tumor stage with eIF4E upregulation and/or HPV genotype was analyzed for 10 normal, 27 cancer, and 37 dysplasia cases. A progressive increase in...
Source: Women's Health Weekly (2006-02-23)
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