Women's Health Weekly
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Apoptosis
Inhibition of P13K/PKB signaling did not directly result in apoptosis in cancer
March 2nd, 2006
Inhibition of P13K/PKB signaling did not directly result in apoptosis in several cancer cell lines. According to a study from England, "Indole-3-carbinol has been proposed to induce apoptosis via a mechanism involving inhibition of protein kinase B (PKB) signaling in breast and prostate tumor cell lines. However, no functional data exist, and the effect of indole-3-carbinol on viability is known to be highly cell type specific." "Here, we examine any requirement for PKB inhibition in induction of apoptosis by indole-3-carbinol in the MDA MB468 cell line using in vitro kinase assays, transfection, Western blotting, and flow cytometry. Comparison is...
Source: Women's Health Weekly (2006-03-02)
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