Bone Development
Bone morphogenetic protein-15 helps regulate oocyte maturation
Published in Women's Health Weekly, March 2nd, 2006
"BMP-15 is a member of the TGFbeta family known to regulate ovarian functions in mammals. The structure and function of BMP-15 in lower vertebrates are less known."
"In this study," wrote E. Clelland and colleagues, York University, "we cloned the zebrafish BMP-15 (zfBMP-15) cDNA and depicted its genomic organization."
"The zfBMP-15 cDNA encodes a protein of 384 amino acids. The mature protein has 46-51% sequence identities to fugu, chicken, and mammalian BMP-15. It also shares 38-46% homology with growth and differentiation...
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