Women's Health Weekly
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Breast Cancer
HER-1 and HER-2 overexpression linked to adverse prognosis in breast cancer
March 2nd, 2006
HER-1 and HER-2 overexpression and lack of BRCA1 expression were separately linked to adverse prognosis in sporadic breast cancer (SBC). According to a study from France, "The BRCA1 caretaker gene is associated with poor prognostic features in hereditary breast cancer and may also play a role in SBC. HER-1 and HER-2 overexpression is associated with adverse prognosis in SBC." "We studied whether BRCA1 expression was associated with HER1, HER2 and other prognostic features in SBC. Fifty newly-diagnosed SBC patients were studied for prognostic features and immunohistochemical expressions of BRCA1, HER-1 and HER-2. Tumors were positive for BRCA1 in 26%,...
Source: Women's Health Weekly (2006-03-02)
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