Women's Health Weekly
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Allergy & Immunology
Mice lacking T-cell protein develop lupus-like disease
March 2nd, 2006
Genetically modified mice that don't produce a particular T-cell protein develop spontaneous autoimmunity and lupus-like disease, researchers report. Proper defense of the body against germs requires the actions of specialized cells of the immune system, known as T cells. Activated T cells must eventually be silenced, or autoimmune diseases such as systemic lupus erythematosus (SLE, or lupus) can result. Alessandra Pernis and colleagues at Columbia University in New York report that genetically modified mice that do not express a T-cell protein called IBP (interferon regulatory factor-4-binding protein) develop spontaneous autoimmunity and lupus-like...
Source: Women's Health Weekly (2006-03-02)
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