Women's Health Weekly
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Breast Cancer
E2F-HDAC complexes negatively regulate breast cancer tumor suppressor gene
March 9th, 2006
According to recently published research from the United States, E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. "ARHI is a maternally imprinted tumor suppressor gene whose expression is markedly downregulated in breast cancer. Reactivation of ARHI expression in breast cancer cells is associated with increased histone H3 acetylation and decreased lysine 9 methylation of histone H3." "An ARHI promoter segment that spanned bases -420 to +58 (designated the P2 region) exhibits significantly higher promoter activity in normal cells than in cancer cells. To better understand the molecular mechanisms contributing to...
Source: Women's Health Weekly (2006-03-09)
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