Women's Health Weekly
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Breast Cancer
Idarubicin displayed cytotoxic effect on breast cancer multicellular spheroids
March 9th, 2006
Idarubicin displayed cytotoxic effect on breast cancer multicellular spheroids. According to recent research published in the Journal of Chemotherapy, "Despite extensive preclinical evaluation in several experimental models, no studies have determined the effect of idarubicin and its metabolite idarubicinol on multicellular spheroids, a model which mimics the microregions of solid tumors. The principal aim of the present study was to investigate the in vitro cytotoxicity of idarubicin and its metabolite idarubicinol on MCF-7 breast cancer cells growing as monolayers or multicellular spheroids and to evaluate the influence of the length of exposure on the...
Source: Women's Health Weekly (2006-03-09)
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