Women's Health Weekly
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Breast Cancer
Stat3 signaling induces survivin gene expression and apoptosis resistance in breast cancer cells
March 9th, 2006
According to recent research from the United States published in the journal Clinical Cancer Research, persistent activation of signal transducer and activator of transcription 3 (Stat3) signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. "Stat3 protein is persistently activated in breast cancer and promotes tumor cell survival. To gain a better understanding of the role of constitutive Stat3 signaling in breast cancer progression, we evaluated the expression profile of potential Stat3-regulated genes that may confer resistance to apoptosis," wrote T. Gritsko and colleagues, City of Hope National Medical...
Source: Women's Health Weekly (2006-03-09)
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