Women's Health Weekly
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Breast Cancer
Three new human BRCA1 mutant cell lines could aid in understanding the function of BRCA1
March 9th, 2006
Three new human BRCA1 mutant cell lines could aid in understanding the function of BRCA1. "Germ line mutations of the BRCA1 gene confer a high risk of breast cancer and ovarian cancer to female mutation carriers. The BRCA1 protein is involved in the regulation of DNA repair," researchers in Netherlands reported. "How specific tumor-associated mutations affect the molecular function of BRCA1, however, awaits further elucidation. Cell lines that harbor BRCA1 gene mutations are invaluable tools for such functional studies. Up to now, the HCC1937 cell line was the only human breast cancer cell line with an identified BRCA1 initiation. In this study, we...
Source: Women's Health Weekly (2006-03-09)
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