Women's Health Weekly
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Cancer Therapy
Studies add new findings to cancer therapy body of knowledge
March 9th, 2006
New findings from Israel, France and Austria describe advances in cancer therapy. Study 1: Novel extracellular vesicles could mediate anticancer drug sequestration and resistance. According to recent research from Israel, "Overexpression of the multidrug efflux transporter ABCG2 in the plasma membrane of cancer cells confers resistance to various anticancer drugs, including mitoxantrone. Here, we explored the mechanism underlying drug resistance in the MCF-7 breast cancer sublines MCF-7/MR and MCF-7/FLV1000 cells in which wild-type (11482) ABCG2 overexpression is highly confined to cell-cell attachment zones." "The latter...
Source: Women's Health Weekly (2006-03-09)
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